Probiotic Studies in Neonatal Mice Using Gavage

Long-term drug administration in the adult zebrafish using oral gavage for cancer preclinical studies

Zebrafish are a major model for chemical genetics, and most studies use embryos when investigating small molecules that cause interesting phenotypes or that can rescue disease models. Limited studies have dosed adults with small molecules by means of water-borne exposure or injection techniques. Challenges in the form of drug delivery-related trauma and anesthesia-related toxicity have excluded...

Asynchronous Synapse Elimination in Neonatal Motor Units Studies Using GFP Transgenic Mice

In developing muscle, synapse elimination reduces the number of motor axons that innervate each postsynaptic cell. This loss of connections is thought to be a consequence of axon branch trimming. However, branch retraction has not been observed directly, and many questions remain, such as: do all motor axons retract branches, are eliminated branches withdrawn synchronously, and are withdrawing ...

Comment on the significance of positive carcinogenicity studies using gavage as the route of exposure.

There is continuing controversy, extending into regulatory matters, over the significance to human health of positive results in carcinogenicity studies in animals using the gavage technique as the route of exposure. Our review of a nonrandom sample of 117 chemicals or chemical processes listed as known or reasonably anticipated to be carcinogenic in the National Toxicology Program's Third Annu...

Clinical Studies of Probiotic Agents

The deliberate addition of microorganisms to the diet of humans dates back to ancient times. Initially, these were probably ingested in the form of fermented milk products, where the bacteria were used to preserve dairy foods. The popularity of dairy products containing "cultures," in the form of yogurt and other fermented milks, has not only withstood the test of time, but their consumption ha...

Éditorial: Gavage des oies